银屑病
伊米奎莫德
医学
免疫学
CD11c公司
免疫系统
钙泊三醇
皮肤病科
生物
生物化学
基因
表型
作者
Kai Wen,Wu Li,Cheng Chen,Xie Weige,Jia-Qi Chen,Shiyu Song,Lingyan Huang,Hongwei Wang,Sijing Xie
出处
期刊:Heliyon
[Elsevier]
日期:2023-02-01
卷期号:9 (2): e13337-e13337
标识
DOI:10.1016/j.heliyon.2023.e13337
摘要
Psoriasis is an autoimmune disease, which has a significant impact on the quality of patient's life. And, there is still no cure for psoriasis. The human dental pulp stem cell (hDPSC) possesses the properties of immunoregulation. In this study, we aimed to determine the effect of hDPSC on the imiquimod (IMQ)-induced psoriasis in mice. The psoriasis model was established by topical application of IMQ cream in mice for 7 days. We found that subcutaneous injection of hDPSC could reduce the symptoms of skin lesions in IMQ-induced psoriasis and suppress the expression of keratin 16, S100A8, S100A9, which are associated with abnormal epidermal proliferation. Subepithelial inflammatory cytokines, CD4+ T lymphocytes and CD11c+ dendritic cells infiltrations were significantly inhibited in by hDPSC. The TNF-α, IFN-γ expressions in serum were decreased, and splenomegaly induced by IMQ was improved after hDPSC treatment. In summary, our study demonstrated that hDPSC could reduce the symptoms of skin lesions and suppress local and systemic immune responses of IMQ-induced psoriasis in mice, which might provide a new sight for the treatment of psoriasis.
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