区域选择性
钯
炔烃
催化作用
三键
废止
硅烷化
化学
药物化学
双键
有机化学
作者
Mamoru Tobisu,Tetsuya Inagaki,Tetsu Ando,Shun Sakurai,Masahiro Yamanaka
出处
期刊:Chemical Science
[The Royal Society of Chemistry]
日期:2023-01-01
卷期号:14 (10): 2706-2712
被引量:4
摘要
Palladium-catalyzed addition of a C-Si bond in acylsilanes across the triple bonds in an alkyne bearing a carbonyl group at one terminal is reported. The reaction proceeds with excellent regioselectivity, in which a silyl group is incorporated into the carbon α to the carbonyl group, allowing for straightforward access to a variety of functionalized alkenylsilane derivatives. Catalytic synthesis of indanones by annulation between acylsilanes and alkynes with an identical catalytic system is also reported.
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