炎症
血红素
炎症反应
免疫学
程序性细胞死亡
病菌
生物
医学
细胞凋亡
遗传学
生物化学
酶
作者
Fiona Henkel,Luke A.J. O’Neill
标识
DOI:10.1016/j.it.2023.06.008
摘要
PANoptosomes are large cell death-inducing complexes that drive a type of cell death called PANoptosis during infection and inflammation. Sundaram and colleagues recently identified NLRP12 as a PANoptosome that induces PANoptosis in response to heme, TNF, and pathogen-associated molecular patterns (PAMPs), indicating a role for NLRP12 in hemolytic and inflammatory diseases.
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