小眼畸形相关转录因子
转录因子
生物
癌变
背景(考古学)
下调和上调
蛋白质稳态
细胞生物学
计算生物学
癌症研究
癌症
遗传学
基因
古生物学
作者
Roberto Zoncu,Rushika M. Perera
标识
DOI:10.1016/j.trecan.2023.06.005
摘要
The microphthalmia/transcription factor E (MiT/TFE) transcription factors (TFs; TFEB, TFE3, MITF, and TFEC) play a central role in cellular catabolism and quality control and are subject to extensive layers of regulation that influence their localization, stability, and activity. Recent studies have highlighted a broader role for these TFs in driving diverse stress-adaptation pathways, which manifest in a context- and tissue-dependent manner. Several human cancers upregulate the MiT/TFE factors to survive extreme fluctuations in nutrients, energy, and pharmacological challenges. Emerging data suggest that reduced activity of the MiT/TFE factors can also promote tumorigenesis. Here, we outline recent findings relating to novel mechanisms of regulation and activity of MiT/TFE proteins across some of the most aggressive human cancers.
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