Non-small cell lung cancer and the tumor microenvironment: making headway from targeted therapies to advanced immunotherapy

免疫疗法 肿瘤微环境 医学 嵌合抗原受体 免疫系统 靶向治疗 肺癌 癌症 免疫学 癌症研究 肿瘤科 内科学
作者
Anna De Lucia,L. Mazzotti,Anna Gaimari,Matteo Zurlo,Roberta Maltoni,Claudio Cerchione,Sara Bravaccini,Angelo Delmonte,Lucio Crinó,Patricia Borges de Souza,Luigi Pasini,Fabio Nicolini,F. Bianchi,Manel Juan,Hugo Calderón,C Magnoni,Luca Gazzola,Paola Ulivi,Massimiliano Mazza
出处
期刊:Frontiers in Immunology [Frontiers Media]
卷期号:16 被引量:1
标识
DOI:10.3389/fimmu.2025.1515748
摘要

Over the past decades, significant progress has been made in the understanding of non-small cell lung cancer (NSCLC) biology and tumor progression mechanisms, resulting in the development of novel strategies for early detection and wide-ranging care approaches. Since their introduction, over 20 years ago, targeted therapies with tyrosine kinase inhibitors (TKIs) have revolutionized the treatment landscape for NSCLC. Nowadays, targeted therapies remain the gold standard for many patients, but still they suffer from many adverse effects, including unexpected toxicity and intrinsic acquired resistance mutations, which lead to relapse. The adoption of immune checkpoint inhibitors (ICIs) in 2015, has offered exceptional survival benefits for patients without targetable alterations. Despite this notable progress, challenges remain, as not all patients respond favorably to ICIs, and resistance to therapy can develop over time. A crucial factor influencing clinical response to immunotherapy is the tumor microenvironment (TME). The TME is pivotal in orchestrating the interactions between neoplastic cells and the immune system, influencing tumor growth and treatment outcomes. In this review, we discuss how the understanding of this intricate relationship is crucial for the success of immunotherapy and survey the current state of immunotherapy intervention, with a focus on forthcoming and promising chimeric antigen receptor (CAR) T cell therapies in NSCLC. The TME sets major obstacles for CAR-T therapies, creating conditions that suppress the immune response, inducing T cell exhaustion. To enhance treatment efficacy, specific efforts associated with CAR-T cell therapy in NSCLC, should definitely focus TME-related immunosuppression and antigen escape mechanisms, by combining CAR-T cells with immune checkpoint blockades.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
热情菠萝完成签到 ,获得积分10
刚刚
科研通AI5应助lin采纳,获得10
1秒前
Milou发布了新的文献求助10
1秒前
1秒前
等等发布了新的文献求助10
1秒前
彭于晏应助LING采纳,获得10
2秒前
天天快乐应助宋佳顺采纳,获得10
3秒前
4秒前
5秒前
领导范儿应助yang采纳,获得20
5秒前
Sui完成签到,获得积分10
5秒前
吴媛媛发布了新的文献求助20
5秒前
kll9797发布了新的文献求助10
5秒前
CipherSage应助自然代亦采纳,获得10
5秒前
123完成签到,获得积分10
6秒前
许甜甜鸭完成签到,获得积分10
6秒前
英姑应助简单的梦菡采纳,获得10
6秒前
7秒前
华仔应助fd163c采纳,获得30
7秒前
路过你的夏完成签到,获得积分20
11秒前
12秒前
zzz完成签到,获得积分10
12秒前
12秒前
12秒前
重要的板凳完成签到,获得积分10
13秒前
13秒前
Xiaoxiao应助橙子采纳,获得20
13秒前
Jiayou Zhang完成签到,获得积分10
13秒前
111完成签到,获得积分10
14秒前
简单的梦菡完成签到,获得积分10
14秒前
醍醐不醒完成签到,获得积分10
15秒前
打打应助kll9797采纳,获得10
15秒前
yang发布了新的文献求助20
17秒前
17秒前
醍醐不醒发布了新的文献求助50
18秒前
糊涂的麦片完成签到,获得积分10
19秒前
loma完成签到 ,获得积分10
19秒前
桐桐应助yyyyyyy采纳,获得10
20秒前
Dawn完成签到 ,获得积分10
21秒前
21秒前
高分求助中
Chinesen in Europa – Europäer in China: Journalisten, Spione, Studenten 500
Arthur Ewert: A Life for the Comintern 500
China's Relations With Japan 1945-83: The Role of Liao Chengzhi // Kurt Werner Radtke 500
Two Years in Peking 1965-1966: Book 1: Living and Teaching in Mao's China // Reginald Hunt 500
Epigenetic Drug Discovery 500
Hardness Tests and Hardness Number Conversions 300
Knowledge management in the fashion industry 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3816810
求助须知:如何正确求助?哪些是违规求助? 3360247
关于积分的说明 10407179
捐赠科研通 3078205
什么是DOI,文献DOI怎么找? 1690660
邀请新用户注册赠送积分活动 813983
科研通“疑难数据库(出版商)”最低求助积分说明 767924