肺病
化学
药理学
疾病
重症监护医学
内科学
医学
作者
Paolo Bruno,Daniele Pala,Alessandra Micoli,Mauro Corsi,Alessandro Accetta,Laura Carzaniga,Paolo Ronchi,Claudio Fiorelli,Michele Formica,Daniela Pizzirani,Roberta Mazzucato,Sara Guariento,Serena Bertolini,Cataldo Martucci,A. D. Allen,Valentina Mileo,Silvia Capacchi,Paola Gallo,Alessandro Fioni,Sara Gutiérrez Fernández
标识
DOI：10.1021/acs.jmedchem.4c02062
摘要
The design of inhaled selective phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitors for the treatment of inflammatory lung diseases was pursued. Knowledge-based design of a novel isocoumarin scaffold that was able to adopt a
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