化学
氧化还原
脱羧
有机化学
碳纤维
活性炭
联轴节(管道)
催化作用
高分子化学
光化学
材料科学
环境保护
环境科学
复合数
冶金
复合材料
作者
Xu-cheng Gan,Benxiang Zhang,Nathan Dao,Cheng Bi,Maithili Pokle,Liyan Kan,Michael R. Collins,Chet Tyrol,Philippe Bolduc,Michael C. Nicastri,Yu Kawamata,Phil S. Baran,Ryan A. Shenvi
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-04-05
卷期号:384 (6691): 113-118
标识
DOI:10.1126/science.adn5619
摘要
The synthesis of quaternary carbons often requires numerous steps and complex conditions or harsh reagents that act on heavily engineered substrates. This is largely a consequence of conventional polar-bond retrosynthetic disconnections that in turn require multiple functional group interconversions, redox manipulations, and protecting group chemistry. Here, we report a simple catalyst and reductant combination that converts two types of feedstock chemicals, carboxylic acids and olefins, into tetrasubstituted carbons through quaternization of radical intermediates. An iron porphyrin catalyst activates each substrate by electron transfer or hydrogen atom transfer, and then combines the fragments using a bimolecular homolytic substitution (S H 2) reaction. This cross-coupling reduces the synthetic burden to procure numerous quaternary carbon–containing products from simple chemical feedstocks.
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