哮喘
医学
重症监护医学
流行病学
哮喘管理
哮喘的病理生理学
疾病
疾病管理
儿科
内科学
帕金森病
作者
Celeste Porsbjerg,Erik Melén,Lauri Lehtimäki,Dominick Shaw
出处
期刊:The Lancet
[Elsevier]
日期:2023-03-01
卷期号:401 (10379): 858-873
被引量:108
标识
DOI:10.1016/s0140-6736(22)02125-0
摘要
Asthma is one of the most common chronic non-communicable diseases worldwide and is characterised by variable airflow obstruction, causing dyspnoea and wheezing. Highly effective therapies are available; asthma morbidity and mortality have vastly improved in the past 15 years, and most patients can attain good asthma control. However, undertreatment is still common, and improving patient and health-care provider understanding of when and how to adjust treatment is crucial. Asthma management consists of a cycle of assessment of asthma control and risk factors and adjustment of medications accordingly. With the introduction of biological therapies, management of severe asthma has entered the precision medicine era-a shift that is driving clinical ambitions towards disease remission. Patients with severe asthma often have co-existing conditions contributing to their symptoms, mandating a multidimensional management approach. In this Seminar, we provide a clinically focused overview of asthma; epidemiology, pathophysiology, diagnosis, and management in children and adults.
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