Treatment of purely cutaneous ​Rosai–Dorfman disease with topical rapamycin

Purely cutaneous Rosai–Dorfman disease is a self-limiting and benign histiocytosis; however, some patients may be concerned about the aesthetic appearance, with a negative effect on quality of life. Even though many treatments have been proposed, no specific therapies are available and there is insufficient evidence supporting the superiority of any particular approach. Here we report the improvement of purely cutaneous Rosai–Dorfman disease with topical rapamycin.