Supramolecular solvents for multi-target and matrix-independent sample preparation

The development of sample treatments based on supramolecular solvents (SUPRAS) has rapidly increased during the last decade. The reasons behind this interest are, among others, the need for more sustainable solvents, but above all, the demand for more efficient and fit-for-purpose sample treatments that face the current challenges confronted by analytical laboratories and some cutting-edge research areas. One of the most outstanding features of SUPRAS is their huge potential for designing ad-hoc sample treatments that solve specific analytical and operational issues. In this article, this potential is exemplified with the achievements obtained in two demanding areas: the screening/quantification of multiclass compounds and the development of matrix-independent analytical methods. We also highlight the need for development of knowledge-based tailoring of solvents that provide fit-for-purpose sample treatments in areas where current methodologies are not applicable or need better performance.