Correlation analysis between CYP2C9 polymorphisms and liver injury induced by flurbiprofen axetil in 100 Han Chinese patients.

This study explored correlation between CYP2C9 polymorphisms and liver injury induced by flurbiprofen axetil (FBA). A total of 100 patients undergoing primary total knee arthroplasty (TKA) were mainly administered with basic analgesic, FBA. All the patients participating in this study were required to take blood samples for detecting CYP2C9 polymorphisms before surgery after admission. After TKA surgery, the level of glutamic-pyruvic transaminase in blood was detected to determine whether liver injury occurred in patients. The overall incidence of liver injury after TKA was 12.00% and the incidence of liver injury was 12.22% for CYP2C9*1/*1 and 16.67% for CYP2C9*1/*3. The incidence of liver injury in patients with CYP2C9*1/*3 was higher than the incidence of overall patients and patients with CYP2C9*1/*1, but the difference was not statistically significant. However, given the occurrence of liver injury, clinicians should still pay attention to patients with CYP2C9*1/*3 to avoid serious liver injury that may be induced by FBA.