Differentiating spinal pathologies by deep learning approach

Spinal pathologies are diverse in nature and, excluding trauma and degenerative diseases, includes infectious, neoplastic (either extradural or intradural) and inflammatory conditions. The preoperative diagnosis is made with clinical judgment incorporating lab findings and radiological studies. When the diagnosis is uncertain, a biopsy is almost always mandatory since the treatment is dictated by the type of pathology. This is an invasive, timely and costly process.The aim of this study was to develop a deep learning (DL) algorithm, based on preoperative MRI and post-operative pathological results, to differentiate between leading spinal pathologies.We retrospectively collected and analyzed clinical, radiological, and pathological data of patients who underwent spinal surgery or biopsy for various spinal pathologies between 2008-2022 at a tertiary center. The patients were stratified according to their pathological reports (the threshold for inclusion was set to 25 patients per diagnosis).Preoperative MRI, clinical data and pathological results were processed by a deep learning model built on the Fast.ai framework on top of the PyTorch environment.Two-hundred and thirty-one patients diagnosed with carcinoma (80), infection (57), meningioma (52) or schwannoma (42), were included in our model. The mean overall accuracy was 0.78±0.06 for the validation, and 0.93±0.03 for the test dataset.DL algorithm for differentiation between the aforementioned spinal pathologies, based solely on clinical MRI, proves as a feasible primary diagnostic modality. Larger studies should be performed to validate and improve this algorithm for clinical use.This study provides a proof-of-concept for predicting spinal pathologies solely by MRI based DL technology, allowing for a rapid, targeted and cost-effective work-up and subsequent treatment.