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Deep learning-based age estimation from clinical Computed Tomography image data of the thorax and abdomen in the adult population

胸部(昆虫解剖学) 腹部 医学 人口 断层摄影术 计算机断层摄影术 放射科 人工智能 核医学 计算机科学 解剖 环境卫生
作者
Bjarne Kerber,Tobias Hepp,Thomas Küstner,Sergios Gatidis
出处
期刊:PLOS ONE [Public Library of Science]
卷期号:18 (11): e0292993-e0292993 被引量:7
标识
DOI:10.1371/journal.pone.0292993
摘要

Aging is an important risk factor for disease, leading to morphological change that can be assessed on Computed Tomography (CT) scans. We propose a deep learning model for automated age estimation based on CT- scans of the thorax and abdomen generated in a clinical routine setting. These predictions could serve as imaging biomarkers to estimate a “biological” age, that better reflects a patient’s true physical condition. A pre-trained ResNet-18 model was modified to predict chronological age as well as to quantify its aleatoric uncertainty. The model was trained using 1653 non-pathological CT-scans of the thorax and abdomen of subjects aged between 20 and 85 years in a 5-fold cross-validation scheme. Generalization performance as well as robustness and reliability was assessed on a publicly available test dataset consisting of thorax-abdomen CT-scans of 421 subjects. Score-CAM saliency maps were generated for interpretation of model outputs. We achieved a mean absolute error of 5.76 ± 5.17 years with a mean uncertainty of 5.01 ± 1.44 years after 5-fold cross-validation. A mean absolute error of 6.50 ± 5.17 years with a mean uncertainty of 6.39 ± 1.46 years was obtained on the test dataset. CT-based age estimation accuracy was largely uniform across all age groups and between male and female subjects. The generated saliency maps highlighted especially the lumbar spine and abdominal aorta. This study demonstrates, that accurate and generalizable deep learning-based automated age estimation is feasible using clinical CT image data. The trained model proved to be robust and reliable. Methods of uncertainty estimation and saliency analysis improved the interpretability.

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