作者
Sophia J. Wagner,Daniel Reisenbüchler,Nicholas P. West,Jan Moritz Niehues,Jiefu Zhu,Sebastian Foersch,Gregory Patrick Veldhuizen,Philip Quirke,Heike Grabsch,Piet A. van den Brandt,Gordon Hutchins,Susan D. Richman,Tanwei Yuan,Rupert Langer,Josien C A Jenniskens,Kelly Offermans,Wolfram Mueller,Richard Gray,Stephen B. Gruber,Joel K. Greenson,Gad Rennert,Joseph D. Bonner,Daniel Schmolze,Jitendra Jonnagaddala,Nicholas J. Hawkins,Robyn L. Ward,Dion Morton,Michel Seymour,Laura Magill,Marta Nowak,Jennifer Hay,Viktor H. Koelzer,David N. Church,Christian Matek,Carol Geppert,Chaolong Peng,Cheng Zhi,Xiaoming Ouyang,Jacqueline James,Maurice B. Loughrey,Manuel Salto-Tellez,Hermann Brenner,Michael Hoffmeister,Daniel Truhn,Julia A. Schnabel,Melanie Boxberg,Tingying Peng,Jakob Nikolas Kather,David N. Church,Enric Domingo,Joanne Edwards,Bengt Glimelius,Ismail Gögenür,Andrea Harkin,Jen Hay,Tim Iveson,Emma Jaeger,Caroline Kelly,Rachel Kerr,Noori Maka,Heather Morgan,Karin A. Oien,Clare Orange,Claire Palles,Campbell S.D. Roxburgh,Owen J. Sansom,Mark Saunders,Ian Tomlinson
摘要
Deep learning (DL) can accelerate the prediction of prognostic biomarkers from routine pathology slides in colorectal cancer (CRC). However, current approaches rely on convolutional neural networks (CNNs) and have mostly been validated on small patient cohorts. Here, we develop a new transformer-based pipeline for end-to-end biomarker prediction from pathology slides by combining a pre-trained transformer encoder with a transformer network for patch aggregation. Our transformer-based approach substantially improves the performance, generalizability, data efficiency, and interpretability as compared with current state-of-the-art algorithms. After training and evaluating on a large multicenter cohort of over 13,000 patients from 16 colorectal cancer cohorts, we achieve a sensitivity of 0.99 with a negative predictive value of over 0.99 for prediction of microsatellite instability (MSI) on surgical resection specimens. We demonstrate that resection specimen-only training reaches clinical-grade performance on endoscopic biopsy tissue, solving a long-standing diagnostic problem.