Bilateral multiple blisters of retinal pigment epithelium in a healthy young female

BACKGROUND/ PURPOSE: Multiple serous pigment epithelium detachments (PEDs) have been infrequently reported. We report a case of a young female with bilateral innumerable serosanguinous PEDs, giving an appearance of multiple blisters. METHODS: A 26-year-old female presented with sudden onset diminution of vision in left eye. She had bilateral innumerable translucent blister-like elevations of retinal pigment epithelium (RPE) and a few hemorrhagic blister-like elevations at macula and submacular blood in left eye. Multi-modal fundus imaging was performed. Pneumatic displacement and intravitreal injection of ranibizumab was performed in left eye. RESULTS: optical coherence tomography (OCT) confirmed multiple serous PEDs with pachychoroid morphology in both eyes and few hemorrhagic PEDs at the macula in left eye. The lesions were hypoautofluorescent with a halo of hyperautofluorescence. Fluorescein angiography revealed pooling into the serous PEDs in both eyes and few late leakage points in the area of blocked fluorescence at the macula in left eye. One-month following the intervention, subretinal blood had partially displaced with modest visual acuity gain. However, the patient refused further intravitreal injections. CONCLUSION: Bilateral extensive serous PEDs, to the extent noted in this case, have not been previously reported. A widespread RPE-Bruch's membrane defect is suspected.