Efficacy analysis of Perindopril combined with Indapamide in primary hypertension

Objective:To investigate the hypotensive effect and adverse reactions of Perindopril combined with Indapamide in primary hypertension.Methods:From July 2009 to December 2009 in our department,90 patients diagnosed with essential hypertension were randomized groups,46 cases of treatment group and 44 cases of control group,they were excluded secondary hypertension.These patients stopped taking antihypertensive drugs more than 5 days.Before and after treatment,the blood and urine routine,ECG and blood lipids,blood glucose,liver and kidney function were recorded.The control group treated with Indapamide 2.5 mg/d or 5 mg/d;the treatment group treated with Indapamide 2.5 mg/d and Perindopril 4 mg/d;the curative effect were assessed after 8 weeks.Results:The total effective rate of treatment group was 87.0%,and the control group was 59.1%,the difference was statistically significant(P0.05),and the treatment group had less adverse reactions.Conclusion:Perindopril combined with Indapamide in the treatment of primary hypertension has good effect and less adverse reactions,it is worth popularizing.