Observation of learning,memory and ultrastructure in PS1/APP double transgenic Alzheimer′s disease of mouse model

Objective To observe the learning and memory function and ultrastructure in hippocampus of APP/PS1 double transgenic mice with Alzheimer′s disease(AD).Methods The learning and memory function were measured by water maze and the ultrastructure in hippocampus was observed by transmission electronic microscopy(TEM).Results The escape latency in the APP/PS1 double transgenic mice was longer than that of the mice in the control.No significant difference was found in the probe trial testing.TEM showed that nerve cells were swollen and synapse loosen in hippocampus of APP/PS1 double transgenic mice of AD.Conclusion The double transgenic APP/PS1 mice of AD can simulate the specific pathogenesis of AD,which may be the efficient experimental animal model.