Study on Preparation and Liver Targeting of Resveratrol Liposomes

Objective: To establish whether liver targeting for resveratrol liposomes is better than resveratrol.Methods: Resveratrol liposomes were prepared using film ultrasonic dispersion method,then resveratrol and its liposomes were injected from mouse tail vein. The resveratrol's concentrations of mouse liver were measured using UV spectrophotometry and used as the investigation indexes. In order to determine the liver targeting differences between resveratrol and its liposomes we compaed the remainings of resveratrol in livers which injected resveratrol and its liposomes after 30 minutes,2 hours and 8 hours,respectively. Results: There was a larger resveratrol distribution amount in mice liver tissues by injecting resveratrol liposomes than resveratrol simply after 30 minutes,2 hours and 8 hours. Conclusion: Resveratrol liposomes possess better effect of liver targeting.