材料科学
甲基丙烯酸酯
抗菌剂
表皮葡萄球菌
紫外线固化
乙二醇
核化学
乙二醇二甲基丙烯酸酯
固化(化学)
X射线光电子能谱
高分子化学
部分
涂层
作者
Jie Zhao,William Millians,Saide Tang,Tiehang Wu,Lei Zhu,Weihua Ming
标识
DOI:10.1021/acsami.5b04633
摘要
We designed and synthesized a novel quaternary ammonium methacrylate compound (QAC-2) bearing a perfluoroalkyl tail on one end and an acrylic moiety on the other. Via one-step UV curing of QAC-2 and methyl methacrylate (MMA) with ethylene glycol dimethacrylate (EGDMA) as the cross-linker, we obtained cross-linked coatings with excellent antimicrobial property, as demonstrated by the total kill against both Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus epidermidis (S. epidermidis) at a QAC-2 concentration as low as ∼0.06 mol % (∼0.4 wt %) relative to MMA, which was substantially lower than the QAC amount needed in the coatings containing QACs with a hydrocarbon tail. A zone of inhibition test confirmed that the antimicrobial effect was on the basis of contact killing and there was no leaching of antimicrobial species from the cross-linked coating. The high antimicrobial potency in QAC-2-containing films was the consequence of strong surface enrichment of the fluorinated QAC, as confirmed by X-ray photoelectron spectroscopy (XPS).
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