Objective To study the preparation and processing technology in order to improve the stability of paeonol in Ye Re Qing Granules.MethodsThe paeonol-β-CD complex was prepared using a saturated solution method and orthogonal method was used to screen the technological process.Results The optimum inclusion condition of paeonol was paeonol : β-CD in proportion as 1∶12,keeping temperature at 50 ℃ for 1.0 h.ConclusionThe stability of paeonol in YeReQing granules can be significantly improved after being made to paeonol-β-CD complex.