小RNA
DNA甲基化
基因沉默
癌变
生物
癌症研究
甲基转移酶
肺癌
甲基化
抑制器
转移
癌症
基因表达
基因
遗传学
医学
病理
作者
Dhirendra Kumar Singh,Sudeep Bose,Sachin Kumar
出处
期刊:Biomarkers
[Informa]
日期:2016-04-27
卷期号:21 (7): 589-599
被引量:9
标识
DOI:10.3109/1354750x.2016.1171906
摘要
Differential expression of miRNAs has been linked with lung carcinogenesis. Recent studies have indicated that DNA hypermethylation can lead to silencing of tumor suppressor miRNA-encoding genes. Restoration of tumor suppressor miRNAs using inhibitors of DNA methyltransferases has been shown to suppress cell proliferation, angiogenesis, invasion and metastasis implying that modulation of methylation of specific miRNAs can be used as novel therapeutic targets in lung cancer. In this review, we highlight tremendous progress which has been made in the identification of methylation-mediated silencing of miRNAs and their contribution in lung carcinogenesis along with the clinical utility of methylated miRNAs.
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