Objective To study the clinical effect of fluconazole combined with amphotericin B for treatment of fungal corneal ulcer.Methods The clinical data of 48 cases(eyes)with fungal corneal ulcer who were treated with fluconazole and amphotericin B were analyzed.Results Among 48 cases(eyes),40 cases(eyes)were healed completely,5 cases(eyes)recoveryed partly and 3 cases(eyes)was not controlled,the recoveryed rate was 83.3% and the total effective rate was 93.75%.Conclusion The combination use of fluconazole and amphotericin B has certain effect for fungal corneal ulcer,which is worth popularizing.