Intravenous Hedgehog Agonist Induces Proliferation of Neural and Oligodendrocyte Precursors in Rodent Spinal Cord Injury

There was a significant increase in the number of O4-positive oligodendrocyte precursors compared with uninjured controls and BrdU-positive cells, reproducing the findings of previous studies using direct Shh protein injection, which demonstrated spared white matter and increased recovery.