血管收缩
充血
血管舒张
神经血管束
神经科学
平衡
内皮
血管舒缩
细胞外
医学
生物
解剖
麻醉
内科学
细胞生物学
血流
作者
Valéria Marques Figueira Muoio,Pontus B. Persson,Mauricio Sendeski
摘要
The cerebral hyperaemia is one of the fundamental mechanisms for the central nervous system homeostasis. Due also to this mechanism, oxygen and nutrients are maintained in satisfactory levels, through vasodilation and vasoconstriction. The brain hyperaemia, or coupling, is accomplished by a group of cells, closely related to each other; called neurovascular unit (NVU). The neurovascular unit is composed by neurones, astrocytes, endothelial cells of blood–brain barrier (BBB), myocytes, pericytes and extracellular matrix components. These cells, through their intimate anatomical and chemical relationship, detect the needs of neuronal supply and trigger necessary responses (vasodilation or vasoconstriction) for such demands. Here, we review the concepts of NVU, the coupling mechanisms and research strategies.
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