磺达肝素
化学
抗凝剂
抗凝血酶
体内
肝素
衍生工具(金融)
体外
药理学
组合化学
生物化学
静脉血栓栓塞
血栓形成
外科
医学
经济
生物技术
金融经济学
生物
作者
Guoqiang Zhang,Honglin Jin,Yunyan Zhao,Lina Guo,Gao Xue,Xiaoxue Wang,Shiyang Tie,Jie Shen,Peng George Wang,Hao Gan,Hui-Fei Cui,Wei Zhao
标识
DOI:10.1016/j.ejmech.2016.12.004
摘要
Fondaparinux, a synthetic pentasaccharide anticoagulant based on heparin antithrombin-binding domain, is derived from a chemical synthesis with more than 50 steps. Herein, we identified nine analogues separated from commercially available crude fondaparinux sodium, and tested their anticoagulant activity in vitro. Based on the activity results, the most active derivative Rrt1.17 was chemically synthesized. Biological properties in vitro and in vivo indicated that the well-defined derivative Rrt1.17 was a more efficient anticoagulant candidate compared with fondaparinux.
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