Application of Toxicogenomics in Drug Discovery

This chapter contains sections titled: Introduction Toxicogenomics Objectives and Study Design Toxicogenomics as a Predictive Tool In vivo Toxicogenomics Using Liver as a Target Organ for Characterizing Mechanisms of Toxicity Monitoring Expression Changes of Drug Metabolizing Enzymes Using Genomics Application of In Vivo Toxicogenomics to Nonhepatic Tissues In vitro Toxicogenomics Toxicogenomics of Human Cell Culture Systems Use of Toxicogenomics for Detection of Idiosyncratic Drug Reactions Use of Toxicogenomics to Further Characterize Potential Animal Models Use of In Vitro Toxicogenomics for Understanding IDRs Summary References