化学
刺激
色谱法
剂型
药物输送
原位
阿江榄仁
生物利用度
终结者
药理学
传统医学
医学
有机化学
免疫学
作者
Sobia Noreen,Shazia Akram Ghumman,Fozia Batool,Bushra Ijaz,Maryam Basharat,Shazia Noureen,Tusneem Kausar,Shahid Iqbal
标识
DOI:10.1016/j.ijbiomac.2019.10.193
摘要
Poor availability is the major barrier to accept the new smart gel system as a preferred ophthalmic solution for various eye problems. Smart gel system especially derived from natural source allows the rapid transition of ocular solution into gel form upon contact to tear solution. The present experimental scheme was intended to prepare and characterize a pH triggered in situ gelling system using moxifloxacin HCl (MOX-HCl). Gum was extracted from Terminalia arjuna bark resin and used as gelling agent in blend with sodium alginate. Sterilized formulations were developed and characterized for their physicochemical attributes. These were further investigated for microbiological testing and eye irritation studies. Drug loaded in situ gel was appeared as clear sol that converted into gel phase in presence of tear solution. Optimized formulation was stable, therapeutically efficacious, non-irritant and has a sustained release of the drug for twelve hours period. Instillation of MOX-HCl loaded in situ gel did not cause any type of irritation symptoms like redness, inflammation and excessive tear production in rabbits as compared to control. MOX-HCl loaded in situ gel can be appraised as a substitute for conventional eye drops for extended precorneal retention, improved corneal permeability along with better ocular bioavailability.
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