医学
帕金森病
分子成像
神经科学
Pet成像
神经影像学
多巴胺
皮质基底变性
病理
正电子发射断层摄影术
核医学
进行性核上麻痹
疾病
内科学
精神科
心理学
生物
体内
生物技术
作者
Kirk A. Frey,Nicolaas I. Bohnen
出处
期刊:Pet Clinics
[Elsevier]
日期:2021-04-01
卷期号:16 (2): 261-272
标识
DOI:10.1016/j.cpet.2020.12.002
摘要
Advances in molecular PET imaging of neurodegenerative parkinsonism are reviewed with focus on neuropharmacologic radiotracers depicting terminals of selectively vulnerable neurons in these conditions. Degeneration and losses of dopamine, norepinephrine, serotonin, and acetylcholine imaging markers thus far do not differentiate among the parkinsonian conditions. Recent studies performed with [18F]fluorodeoxyglucose PET are limited by the need for automated image analysis tools and by lack of routine coverage for this imaging indication in the United States. Ongoing research engages use of novel molecular modeling and in silico methods for design of imaging ligands targeting these specific proteinopathies.
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