DNA甲基化
男性不育
表观遗传学
精子
不育
生物
精液质量
精液
甲基化
男科
精子发生
精子质量
基因组印记
基因
遗传学
怀孕
医学
基因表达
作者
Weikang Chen,Dongdong Yu,Yupeng Liu,Zhigang Wu
出处
期刊:Chinese journal of medical genetics
日期:2021-02-01
卷期号:38 (2): 188-193
标识
DOI:10.3760/cma.j.cn511374-20200221-00093
摘要
DNA methylation as an important aspect of epigenetics plays an important role in spermatogenesis and embryonic development. In recent years, researchers have found that male infertility, in particular abnormal semen quality, is related to abnormal DNA methylation. To further delineate the pathogenesis of male infertility and inspire new ideas for the treatment of male infertility, a comprehensive review over the correlation between abnormal methylation of imprinted genes, repetitive DNA elements and non-imprinted genes, semen quality (including sperm count, morphology, and vitality) and male infertility is provided.
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