光热治疗
免疫系统
免疫疗法
黑色素瘤
医学
癌症研究
免疫检查点
放射治疗
血栓形成
免疫学
材料科学
内科学
纳米技术
作者
Xuan Yi,Hailin Zhou,Yu Chao,Saisai Xiong,Jing Zhong,Zhifang Chai,Kai Yang,Zhuang Liu
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2020-08-14
卷期号:6 (33)
被引量:151
标识
DOI:10.1126/sciadv.aba3546
摘要
We discovered that attenuated Salmonella after intravenous injection would proliferate within various types of solid tumors but show rapid clearance in normal organs, without rendering notable toxicity. Bacteria-induced inflammation would trigger thrombosis in the infected tumors by destroying tumor blood vessels. Six types of tested tumors would all turn into darkened color with strong near-infrared absorbance, as observed by photoacoustic imaging. Under laser irradiation, those bacterial-infected tumors would be effectively ablated. Because of the immune-stimulation function, such bacteria-based photothermal therapy (PTT) would subsequently trigger antitumor immune responses, which could be further enhanced by immune checkpoint blockade to effectively suppress the growth of abscopal tumors. A robust immune memory effect to reject rechallenged tumors is also observed after bacteria-based PTT. Our work demonstrates that bacteria by themselves could act as a tumor-specific PTT agent to enable photoimmunotherapy cancer therapy to inhibit tumor metastasis and recurrence.
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