This work deals with theoretical approach and mathematical modeling of hyperthermia effect by single– domain ferro-nanoparticles. The magnetic particles have the Neel relaxation particles of the easy magnetization axes. The system is happened under external magnetic field. Two situations of systems, system of approximation of non-interaction chaotic particles like single particle and system of chain-like two particles are considered into account whereas these particles are in strong magnetic anisotropy. Our analysis shows the chain of particles with strong magnetic anisotropy weakens the thermal effect of hyperthermia under the effect of easy magnetization axes of ferro-nanoparticles.