Using Non-Negative Matrix Factorization to Examine Treatment Resistance and Response in Patients With Schizophrenia: A Multimodal Imaging Study

About 20-40% of patients with schizophrenia experience a limited response to antipsychotic treatment and are deemed to have treatment-resistant schizophrenia (TRS). A multimodal examination of patients with TRS alongside patients who respond to antipsychotic medication [i.e. treatment non-resistant schizophrenia (TnRS)] is necessitated.