Objective To evaluate the effectiveness of health education on non-prescription drugs and family self-medication among normal students.Methods Health education on non-prescription drugs and family self-medication was carried out by multi-media classroom teaching approach.And prevalence survey and cohort study were conducted using self-designed questionnaire on knowledge of non-prescription drugs and family self-medication before and after health education.Results Through the study of public selective courses,the awareness rate of normal students improved remarkably.And the average score(92.0±14.6)was much higher than that of education before(52.2±15.2),with a statistically significant difference(P0.01).The awareness rates on the definition and identification of non-prescription drugs,drug validation,storage conditions and the nature of the drug of viable cells of normal student in exposure group were significantly increased.Moreover,the mastery of knowledge on drug half-life,dosage form characteristics and antibiotics abuse was greatly enhanced as well.Conclusion Providing health education on non-prescription drugs and family self-medication to normal students was not only necessary,but had led to good results.