Species differences of muridae in the learning and memory behavior in morris water maze

Objective To study species differences of Muridae in spatial learning and memory in the Morris water maze. Methods Spague Dawley rats, C57/BL mice and Kunming mice were tested in hidden-platform acquisition training and probe trial testing in Morris water maze in which spatial learning and retention were assessed. Results Rats and mice appeared to use different strategies for locating the hidden escape platform. The escape latency of C57/BL mice was shorter than Spague Dawley rats and Kunming mice. C57/BL mice spent more time (26. 94 s) in the training quadrant. It was longer than other two murine species. Conclusion The species differences exists among three Muridae in the Morris water maze. C57/BL mice has best performance and is most suitable for Morris water maze.