血小板
血小板源性生长因子受体
细胞生物学
血小板衍生生长因子
单核细胞
血管收缩
成纤维细胞
生长因子
促炎细胞因子
血小板活化
免疫学
功能(生物学)
炎症
化学
生物
内分泌学
受体
体外
生物化学
作者
de Gaetano G,Chiara Cerletti,Nanni-Costa Mp,Andreina Poggi
出处
期刊:PubMed
日期:1989-06-01
卷期号:6: 441s-445s
被引量:7
摘要
Platelets seem to be involved in inflammatory responses. They release substances which can cause vasodilation or vasoconstriction. Platelet Derived Growth Factor (PDGF) induces monocyte accumulation and activation and there is evidence that some mediators released from these cells can affect neutrophil migration as well as function. Furthermore, platelet derived cytokines participate in the processes of tissue repair, particularly fibroblast proliferation and matrix remodelling. We review some of the possible mechanisms which have been proposed to explain this role of platelets in the appearance and persistence of inflammatory reactions at the tissue sites.
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