糖尿病
小岛
胰岛
胰岛素
内分泌学
葡萄糖稳态
基因剔除小鼠
内科学
锌
2型糖尿病
生物
基因
医学
化学
生物化学
胰岛素抵抗
有机化学
作者
Pauline Chabosseau,Guy A. Rutter
标识
DOI:10.1016/j.abb.2016.05.022
摘要
Zn2+ ions are essential for the normal processing and storage of insulin and altered pancreatic insulin content is associated with all forms of diabetes mellitus. Work of the past decade has identified variants in the human SLC30A8 gene, encoding the zinc transporter ZnT8 which is expressed highly selectively on the secretory granule of pancreatic islet β and α cells, as affecting the risk of Type 2 Diabetes. Here, we review the regulation and roles of Zn2+ ions in islet cells, the mechanisms through which SLC30A8 variants might affect glucose homeostasis and diabetes risk, and the novel technologies including recombinant targeted zinc probes and knockout mice which have been developed to explore these questions.
科研通智能强力驱动
Strongly Powered by AbleSci AI