Evaluation of the significance of NSE in diagnosis of lung cancer by ROC curve analysis

Objective:To evaluate the significance of neuron-specific enolase(NSE)in diagnosis of lung cancer by ROC curve analysis.Methods:The NSE levels in serum of 123 lung cancer patients and 109 patients with benign lung diseases were analyzed retrospectively and the diagnostic performance of NSE in lung cancer was evaluated with Receiver operating characteristic curve(ROC).Results:① Serum levels of NSE in the three pathological types of lung cancer patients were significantly higher than those in benign lung disease group(P0.01);② The sensitivity,specificity,and area under ROC curve of serum NSE levels in lung cancer patients were respectively 64.2%,67.9% and 0.73%,by ROC curve analysis;③Combined determination of NSE,CEA and CYFRA21-1 had sensitivity of 93.5% for lung cancer diagnosis.Conclusion:The determination of NSE for diagnosis of lung cancer is of value,and the combined determination of NSE,CEA and CYFRA21-1 can increase sensitivity in diagnosis of lung cancer.