Metabolites of Mangrove Endophytic Fungus Gx-3a from the South China Sea

Secondary metabolites were studied from mangrove endophytic fungus No·Gx-3a in the south china sea.The compounds were isolated by column chromatography,and identified on the basia of physic-chemical constants,and spectral analysis.Four metabolites were obtained and elucidated as ditryptophenaline(1),3-hydroxy-4-(2,6,6-trimethyl- tetrahydro- 2H-pyran-2-yl)benzoic acid(2),(E)-4,5-dihydroxy-3-(prop-1-enyl)cyclopent-2-enone(3),3,6-di-sec-butyl-1,4-dihydroxypiperazine-2,5-dione(4).In the preliminary bioassay,ditryptophenaline showes strong inhibittory activity on the KB,KBv200 with LD50 values of 8.0μMol and 12.0μMol,respectively.The four metabolites were obtained from endophytic fungus No·Gx-3a for the first time.