Effect of Xianjia Prescription on the Expression of PCNA in Prostate Tissue of Rats with Benign Prostatic Hyperplasia

Objective To observe prostate weight,epithelia cell height and the expression of PCNA in prostate tissues of the rats with benign prostatic hyperplasia(BPH).Methods The castrated SD male rats were subcutaneously injected with testosterone propionate for 30 days and BPH models were established.Under light microscopy,epithelia cell height was observed and by using immunohistochemistry, the expression of PCNA in prostate tissue was detected.Results The expression of PCNA,prostate weight and epithelial cell height in model group were significantly increased as compared with those in control group(all P0.01).There was no significant difference between Xianjia prescription high dose group and control group(P0.05).Conclusion Xianjia prescription can regulate the expression of PCNA to suppress BPH.