AIM: To evaluate the effects of Beiling Capsule(cordycepic mycelium) on chronic renal failure(CRF). METHODS: 82 cases of CRF were divided into two groups randomly. 42 cases were treated with Beiling Capsule and the usual treatment, while 40 cases were only treated with the usual treatment as the control group, 2 months coustituing a single therapeutic course. RESULTS: In respect to BUN, the total efficiency of the group with Beiling Capsule was 57.1%, while the control group was 30.0%. In respect to Cr, the total efficiency of the group with Beiling Capsule was 59.5%, while the control group was 32.5%. CONCLUSION: Beiling Capsule provides protection against the progression of CRF.