Effect of ~(131)I therapy on differentiated thyroid carcinoma metastases

Objective:To assess the effect of iodine-131(131I)therapy on patients with differentiated thyroid carcinoma metastases.Methods:Forty-five patients with differentiated thyroid carcinoma metastases were treated with 131I,and the dose of 131I varied according to the site of metastasis(370×107 to 740×107)Bq.The therapy was repeated 2 to 8 times at an interval of 4 to 12 months.The efficacy was assessed 4-6 months later with 131I whole body scanning and serum level of thyroglobulin.Results:Of the 45 cases,15 were cured,26 improved and 4 had no response.Conclusions:The therapy of high doses of 131I is safe and effective for treatment of differentiated thyroid carcinoma metastases with little adverse side-effect.