Objective To study the ventilation effects of improved mask on the patients with fiberopic bronchoscopy(FOB) under propofol-fentanyl anesthesia.Methods Eighty-six patients undergoing selective bronchofiberscopy with ASAⅠorⅡ,including 47 males and 39 females,aged at(60.6±10.3) years old,were divided into three groups: lidocaine topical anesthesia group(group A),propofol-fentanyl anesthesia group(group B) and group of propofol-fentanyl anesthesia with improved mask(group C).SBP,DBP,MAP,HR and SpO2were monitored before examination(basic state,T1),at the time of just entering into the glottis(T2),FOB touching the tracheal carina(T3),immediately after pulling out FOB(T4) and 5 min after the patient came round(10 min after the examination for group A was closed)(T5);samples of arterial blood were collected at T1,T3and T5to conduct the analysis of arterial blood gas and to determine the arterial PaO2,PaCO2and pH value;samples of venous blood were collected at T1and T5to determine the plasma cortisol and blood glucose concentration.Results Compared to group C,the SBP,DBP and HR at T3and T4was much higher in group A(P0.05).At the time of T3,PaO2in group B was significantly lower than that in group A and group B,and PaCO2was much higher in group B(P0.05).Compared with T1and group B and group C,cortisol and glucose concentration in group A was significantly higher at T5in group A(P 0.05).Conclusion The improved mask has a good ventilation effect on the patients with fiberopic bronchoscopy under propofol-fentanyl anesthesia and can be used widely in clinic.