Effect of propiverine hydrochloride on urinary bladder contraction

The effects of propiverine hydrochloride (Pro) were investigated on the spontaneous and KCl induced contractions of isolated guinea pig urinary bladder strip and rhythmic urinary bladder contractions of anesthetized dogs. At 1, 10 μmol·L -1 , Pro increased the contraction frequency and amplitude of the isolated guinea pig urinary bladder strips. At 100 μmol·L -1 , it completely inhibited the spontaneous contraction and lowered the baseline. Pro could also significantly inhibit the isolated guinea pig urinary bladder strip contraction induced by KCl, and the IC 50 was (25.2±4.7)μmol·L -1 . At doses of 60 and 30 mg·kg -1 , intraduodenal administration of Pro suppressed the frequency and decreased the amplitude of rhythmic urinary bladder contraction of anesthetized dog in a dose dependent manner. These results indicate that Pro shows an excitatory action on the endogenous spontaneous contractions of urinary bladder in vitro at low concentration but inhibitory effect at high concentration. For the exogenous urinary bladder contraction induced by KCl in vitro and by the Balloon′s method in intact dogs Pro shows a suppressing action and has no exciting effects even at low concentration or low dose. So Pro might become a useful drug for the treatment of micturitional dysfunction such as pollakiuria and urinary incontinence due to its characteristic effects on urinary bladder.