Application of Caco-2 Cell Model to Transportation and Absorption of Toxic Substances

The Caco-2 cell monolayer, isolated from human colon carcinoma,has been wildly used in toxicology study and used as a tool to study the intestinal uptake and transport processes of xenobiotic. We introduces the culture conditions,the basic characteristics and functional parameters of Caco-2 cell monolayer model in brief. The paper also discussed the application of Caco-2 cell monolayer model in studying the mechanism of intestinal transportation and absorption of environmental toxic substances and toxic effects of these substances on their intestinal transportation and absorption in detail. In addition,the application of Caco-2 cells in human health risk assessment for environmental toxic substances is prospected.