Clinical Observation of Shanmei Capsules in the Treatment of Chronic Cerebral Circulation Insufficiency Complicating with Qi-stagnancy and Blood Stasis Syndrome

OBJECTIVE:To observe therapeutic efficacy and safety of Shanmei capsules in the treatment of chronic cerebral insufficiency with qi-stagnancy and blood stasis.METHODS:211 patients were randomly divided into 2 groups in accordance with the ratio of 3∶1,i.e.159 cases in trial group and 52 cases in control group,among which 153 cases of trial group and 50 cases of control group were in line with scheme volume and included in study.Trial group orally received Shanmei capsules 0.75 g,3 times a day;control group was given Xinnaokang capsule 1 g,3 times a day for 4 weeks.After the treatment,clinical efficacy and safety of 2 groups were evaluated.RESULTS:The total effective rates of trial group and control group were 84.96% and 74.00%;there was no statistical significance(P0.05).Total effective rates of TCM syndromatology were 83.00% and 76.00%;there was no statistical significance(P0.05).There was no statistical significance in the change of levels of TG,TC,LDL-C and HDL-C(P0.05).There was no statistical significance in the incidence of ADR between 2 groups during study(P0.05).CONCLUSIONS:Shanmei capsules are effective and safe in the treatment of chronic cerebral insufficiency complicating with Qi-stagnation and blood stasis.