生物
免疫学
细胞因子
转录因子
效应器
获得性免疫系统
自身免疫
表观遗传学
T细胞
细胞生物学
先天性淋巴细胞
免疫系统
细胞分化
遗传学
基因
作者
Jinfang Zhu,Hidehiro Yamane,William E. Paul
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2010-03-01
卷期号:28 (1): 445-489
被引量:2736
标识
DOI:10.1146/annurev-immunol-030409-101212
摘要
CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They are also involved in autoimmunity, asthma, and allergic responses as well as in tumor immunity. During TCR activation in a particular cytokine milieu, naive CD4 T cells may differentiate into one of several lineages of T helper (Th) cells, including Th1, Th2, Th17, and iTreg, as defined by their pattern of cytokine production and function. In this review, we summarize the discovery, functions, and relationships among Th cells; the cytokine and signaling requirements for their development; the networks of transcription factors involved in their differentiation; the epigenetic regulation of their key cytokines and transcription factors; and human diseases involving defective CD4 T cell differentiation.
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