生物
H3K4me3
增强子
表观遗传学
组蛋白
管家基因
基因
发起人
基因表达调控
遗传学
表观遗传学
基因表达
CpG站点
计算生物学
细胞生物学
DNA甲基化
作者
Eva Galle,Chee-Wai Wong,Adhideb Ghosh,Thibaut Desgeorges,Kate Melrose,Laura Hinte,Daniel Castellano‐Castillo,Magdalena Engl,João Agostinho de Sousa,Francisco Javier Ruiz‐Ojeda,Katrien De Bock,Jonatan R. Ruiz,Ferdinand von Meyenn
出处
期刊:Genome Biology
[Springer Nature]
日期:2022-10-03
卷期号:23 (1)
被引量:26
标识
DOI:10.1186/s13059-022-02775-y
摘要
Histone lactylation has been recently described as a novel histone post-translational modification linking cellular metabolism to epigenetic regulation.Given the expected relevance of this modification and current limited knowledge of its function, we generate genome-wide datasets of H3K18la distribution in various in vitro and in vivo samples, including mouse embryonic stem cells, macrophages, adipocytes, and mouse and human skeletal muscle. We compare them to profiles of well-established histone modifications and gene expression patterns. Supervised and unsupervised bioinformatics analysis shows that global H3K18la distribution resembles H3K27ac, although we also find notable differences. H3K18la marks active CpG island-containing promoters of highly expressed genes across most tissues assessed, including many housekeeping genes, and positively correlates with H3K27ac and H3K4me3 as well as with gene expression. In addition, H3K18la is enriched at active enhancers that lie in proximity to genes that are functionally important for the respective tissue.Overall, our data suggests that H3K18la is not only a marker for active promoters, but also a mark of tissue specific active enhancers.
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