Beneficial role of Boehmeria nivea in health and phytochemical constituents

Journal of Food BiochemistryVolume 46, Issue 12 e14474 ORIGINAL ARTICLE Beneficial role of Boehmeria nivea in health and phytochemical constituents Jungwon Choi, Jungwon Choi Department of Plant Science and Technology, Chung-Ang University, Anseong, Republic of KoreaSearch for more papers by this authorQuynh Nhu Nguyen, Quynh Nhu Nguyen Department of Preventive Medicine, Gachon University, Seongnam, Republic of KoreaSearch for more papers by this authorJi Yun Baek, Ji Yun Baek Department of Preventive Medicine, Gachon University, Seongnam, Republic of KoreaSearch for more papers by this authorDa-Eun Cho, Da-Eun Cho orcid.org/0000-0003-4728-2829 Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Republic of KoreaSearch for more papers by this authorKi Sung Kang, Ki Sung Kang Department of Preventive Medicine, Gachon University, Seongnam, Republic of KoreaSearch for more papers by this authorDae-Hyun Hahm, Dae-Hyun Hahm Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Republic of KoreaSearch for more papers by this authorTae Won Jang, Tae Won Jang Department of Pharmaceutical Science, Jungwon University, Goesan, Republic of KoreaSearch for more papers by this authorJae Ho Park, Jae Ho Park Department of Pharmaceutical Science, Jungwon University, Goesan, Republic of KoreaSearch for more papers by this authorAh Young Lee, Corresponding Author Ah Young Lee [email protected] orcid.org/0000-0002-3489-7798 Department of Food Science and Nutrition, Gyeongsang National University, Jinju, Republic of Korea Correspondence Ah Young Lee, Department of Food Science and Nutrition, Gyeongsang National University, Jinju 52828, Republic of Korea. Email: [email protected] Sanghyun Lee, Natural Product Institute of Science and Technology, Anseong 17546, Republic of Korea. Email: [email protected]Search for more papers by this authorSanghyun Lee, Corresponding Author Sanghyun Lee [email protected] orcid.org/0000-0002-0395-207X Department of Plant Science and Technology, Chung-Ang University, Anseong, Republic of Korea Natural Product Institute of Science and Technology, Anseong, Republic of Korea Correspondence Ah Young Lee, Department of Food Science and Nutrition, Gyeongsang National University, Jinju 52828, Republic of Korea. Email: [email protected] Sanghyun Lee, Natural Product Institute of Science and Technology, Anseong 17546, Republic of Korea. Email: [email protected]Search for more papers by this author Jungwon Choi, Jungwon Choi Department of Plant Science and Technology, Chung-Ang University, Anseong, Republic of KoreaSearch for more papers by this authorQuynh Nhu Nguyen, Quynh Nhu Nguyen Department of Preventive Medicine, Gachon University, Seongnam, Republic of KoreaSearch for more papers by this authorJi Yun Baek, Ji Yun Baek Department of Preventive Medicine, Gachon University, Seongnam, Republic of KoreaSearch for more papers by this authorDa-Eun Cho, Da-Eun Cho orcid.org/0000-0003-4728-2829 Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Republic of KoreaSearch for more papers by this authorKi Sung Kang, Ki Sung Kang Department of Preventive Medicine, Gachon University, Seongnam, Republic of KoreaSearch for more papers by this authorDae-Hyun Hahm, Dae-Hyun Hahm Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Republic of KoreaSearch for more papers by this authorTae Won Jang, Tae Won Jang Department of Pharmaceutical Science, Jungwon University, Goesan, Republic of KoreaSearch for more papers by this authorJae Ho Park, Jae Ho Park Department of Pharmaceutical Science, Jungwon University, Goesan, Republic of KoreaSearch for more papers by this authorAh Young Lee, Corresponding Author Ah Young Lee [email protected] orcid.org/0000-0002-3489-7798 Department of Food Science and Nutrition, Gyeongsang National University, Jinju, Republic of Korea Correspondence Ah Young Lee, Department of Food Science and Nutrition, Gyeongsang National University, Jinju 52828, Republic of Korea. Email: [email protected] Sanghyun Lee, Natural Product Institute of Science and Technology, Anseong 17546, Republic of Korea. Email: [email protected]Search for more papers by this authorSanghyun Lee, Corresponding Author Sanghyun Lee [email protected] orcid.org/0000-0002-0395-207X Department of Plant Science and Technology, Chung-Ang University, Anseong, Republic of Korea Natural Product Institute of Science and Technology, Anseong, Republic of Korea Correspondence Ah Young Lee, Department of Food Science and Nutrition, Gyeongsang National University, Jinju 52828, Republic of Korea. Email: [email protected] Sanghyun Lee, Natural Product Institute of Science and Technology, Anseong 17546, Republic of Korea. Email: [email protected]Search for more papers by this author First published: 09 October 2022 https://doi.org/10.1111/jfbc.14474Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract The leaf and stem extracts of Boehmeria nivea (BN) collected from three different regions in Korea were screened for their antioxidant, neuroprotective, estrogenic, insulin secretion, and α-glucosidase inhibitory activity. We also examined whether BN extracts regulate cancer cell growth, inflammatory-related gene expression, and lipid accumulation in cellular system. Leaf extracts possessed greater antioxidant, anti-proliferative in cancer cells, neuroprotective, estrogenic activity, and inhibitory effect on pro-inflammatory gene expression than stem extracts. Leaf and stem extracts inhibited lipid accumulation in three T3-L1 adipocytes but did not affect glucose-stimulated insulin secretion in INS-1 cells. We isolated and identified the phytochemical constituents in the n-butanol and ethyl acetate fractions of BN leaves by combining silica gel column chromatography with mass spectrometry and 1H- and 13C-NMR analysis. The active compounds (caffeic acid, isoquercitrin, p-coumaric acid, and rutin) exhibited ABTS and DPPH radical scavenging activity, which may contribute to the biological activities of BN leaf extract. An analytical method was developed to quantify marker compounds for the discrimination of BN collected from different regions. Our results support the use of this analysis method for accurate identification and quantification of marker compounds in BN for the development of functional foods. Practical applications Boehmeria nivea (BN) has been used as a raw material for the textile industry or traditional herbal medicine. The current study established the biological activities and active components of BN. Our results showed that BN leaf and stem extracts exhibit antioxidant, neuroprotective, and estrogenic activity. BN leaf extract also inhibited cancer cell growth, inflammatory mediators and cytokines production, and lipid accumulation in vitro. Moreover, the bioactive compounds, such as caffeic acid, isoquercitrin, p-coumaric acid, and rutin, exert ABTS and DPPH radical scavenging activities. Therefore, BN could potentially be a promising source of bioactive phytochemicals for the development of functional foods or drugs. CONFLICT OF INTEREST The authors declare that there is no conflict of interest. Open Research DATA AVAILABILITY STATEMENT Data will be provided by the corresponding author up-on request. Volume46, Issue12December 2022e14474 RelatedInformation