胎盘形成
细胞滋养层
吻素
非整倍体
合胞滋养细胞
免疫组织化学
怀孕
男科
生物
内科学
医学
受体
内分泌学
胎盘
免疫学
胎儿
基因
遗传学
染色体
作者
A.O. Abdelkareem,Sahar M. Gebril,F. AbdelHafez,Jefferson Terry,Mohamed A. Bedaiwy
出处
期刊:F&S science
[Elsevier]
日期:2023-02-01
卷期号:4 (1): 56-64
被引量:2
标识
DOI:10.1016/j.xfss.2022.10.002
摘要
To study choriodecidual immunoreactivity of kisspeptin (KISS1) and its receptor (KISS1R) in recurrent pregnancy loss (RPL) due to aneuploidy (AnE) and unexplained (UE) RPL in comparison to control elective abortions (EAbs).This is a case-control study.Tertiary care facility and affiliated research institute.Patients with either UE RPL (n = 10) or RPL due to AnE (n = 10) vs. a control group of patients who underwent EAb (n = 10).Immunohistochemistry of archived choriodecidual tissue samples.Histoscores of KISS1 and KISS1R immunoreactivity in the syncytiotrophoblast (SyT), cytotrophoblast (CyT), decidual glands (DeGs), and decidual stroma (DeS) across the 3 study groups.There was no difference in both maternal and gestational ages among the 3 groups. Kisspeptin immunoreactivity was similar in the SyT, CyT, DeGs, and DeS of all groups. Similarly, KISS1R expression was not different in the DeGs or DeS among all study groups. In addition, there was no difference in KISS1R immunoreactivity in the SyTs and CyTs between patients with RPL due to AnE and those with UE RPL. However, KISS1R was significantly lower in the SyT and CyT of patients with RPL due to AnE and UE RPL than in those who underwent EAb.The expression of KISS1R is lower in the chorionic tissues of euploid (unexplained) and aneuploid RPLs than in the control group. The current results broaden our understanding of the role played by KISS1 and KISS1R in early placentation. Further investigation is necessary to determine whether KISS1 activity is the cause or a sequel of defective placentation.
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