Neuroprotective Effects of Eugenol in Alzheimer's Disease: Mitigating OxidativeStress, Inflammation and Amyloid Plaques

Eugenol, a phenolic phytochemical found in many medicinal plants, exhibits various pharmacologicalproperties, including analgesic, antipyretic, antioxidant, anti-inflammatory, antimicrobial, anticancer, neuroprotective,and anaesthetic effects. It has shown potential in addressing neurodegenerative diseases likeAlzheimer's disease (AD), Parkinson's disease, and motor neuron disease, which are primarily caused bymechanisms such as apoptosis, protein accumulation, aging, and oxidative stress within the central nervoussystem (CNS). This review explores the mechanisms through which eugenol may influence AD. Eugenol appearsto counter oxidative stress, reduce inflammation, and prevent amyloid beta (Aβ) plaque accumulation,suggesting it could delay the onset or progression of AD. However, more research is required to establish itssafety and effectiveness in treating or preventing this disease.